"Handle with Care" is the first track from the Traveling Wilburys' 1988 album, Traveling Wilburys Vol. 1, and the group's most successful single. The song was written primarily by George Harrison, although writing credits are shared by all five members of the Wilburys: Harrison, Jeff Lynne, Roy Orbison, Tom Petty and Bob Dylan.

The single peaked at number 45 on the Billboard Hot 100, number 2 on the Billboard Mainstream Rock Tracks chart, number 21 on the UK Singles Chart,[2] and number 3 on the ARIA Chart.[3] AllMusic journalist Matthew Greenwald describes "Handle with Care" as "one of the most memorable records of the 1980s", adding: "Musically, the song is built around a descending, folk-rock chord pattern and some fine major-key chorus movements. George Harrison handles the verses, and there are also two excellent bridges featuring Roy Orbison and Bob Dylan. Orbison's section capitalizes on his awesome, operatic vocal pipes, and the effect is wonderful."[4] (Wikipedia)

Petty explained to Mojo magazine January 2010 what it was like co-writing a song with Bob Dylan. Said Petty: "There's nobody I've ever met who knows more about the craft of how to put a song together than he does. I learned so much from just watching him work. He has an artist's mind and can find in a line the key word and think how to embellish it to bring the line out. I had never written more words than I needed, but he tended to write lots and lots of verses, then he'll say, this verse is better than that, or this line. Slowly this great picture emerges. He was very good in The Traveling Wilbur's: when somebody had a line, he could make it a lot better in big ways." (Songfacts)